Introduction: De-Quervain disease is a stenosing tenosynovitis due to inadequacy volume between abductor pollicis longus, extensor pollicis brevis and their tunnel. Treatment method includes immobilization, steroid injections and operation. For the first time Fritz De Quervain described surgical treatment of this disease. Since then various ways of treatment have been reported.

Aim and Objective: The aim of this study was to evaluate the clinical outcome of various incisions in the management of De-Quervain disease.

Materials and Methods: In this study a total of 45 patients with De Quervain’s tenosynovitis confirmed by clinical examination, USG and with pain interfering with daily activities of life were taken.

Results: Mean VAS score in the longitudinal incision group reduced from 9.33±0.617 (range 8-10) to 1.27±0.458 (range 1-2), in the transverse incision group from 9.53±0.640 (range 8-10) to 1.73±0.704 (range 1-3) and in the oblique incision group from 9.40±0.737 (range 8-10) to 1.60±0.828 (range 1-3). The P-value for all this data shows significant reduction from 0.734 (pre-operative) to 0.167 (post-operative). The prevalence of nerve damage in longitudinal incision group was 0.0% while as it was 13.3% in both transverse and oblique groups with a P-value of 0.334.

Conclusion: Compared to the other two incisions, the longitudinal incision is a safe and simple procedure because it makes it simple to identify compartment variations, superficial radial nerve branches, the cephalic vein, and it prevents palmar tendon subluxation by releasing the compartment sheath more dorsally.