Introduction: Complex regional pain syndrome (CRPS) also known as reflex sympathetic dystrophy (RSD) and causalgia is a disorder of a body region, usually of the extremities that is characterized by pain, swelling, limited range of motion. It frequently begins following an injury, surgery, or vascular event such as a stroke. Vitamin C has been proposed to prevent the incidence of complex regional pain syndrome (CRPS).

Aim and Objectives: The aim of this study was to assess the efficacy of vitamin C prophylaxis in the prevention of Complex regional pain syndrome (CRPS) Complex regional pain syndrome (CRPS) in patients after distal end radius fractures.

Materials and Methods: This prospective and randomized study was conducted on 126 patients from August 2018 to July 2020 in the department of orthopaedics, Govt. Medical College Srinagar. In this study the enrolled patients were evaluated from OPD and emergency department. The enrolled patients were distributed in two groups A (66 patients) and B (60 patients). Patients treated with either conservative or surgical management for distal end radius fractures. In group A patients were given vitamin C with standard therapy and group B patients were given standard therapy alone. In both groups the treatment was given for the period of 3 months.

Results: The complex regional pain syndrome (CRPS) was 12.12% in group A and 21.66% in group B.

Conclusion: In this study it has been prevailed that daily administration of 500 mg of vitamin C prophylaxis could reduce the development of complex regional pain syndrome (CRPS) in patients after distal end radius fractures.